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AboutPricing
Drug ReportsCitric acid monohydrate
Citric acid
/ /, Clenpiq, G, Idkit:hp, Phexxi, Renacidin (citric acid) is a small molecule pharmaceutical. Citric acid was first approved as Irrigating solution g in plastic container on 1982-06-22. It is used to treat renal tubular acidosis and urination disorders in the USA. It is known to target polycystin-2-like protein 1 and transient receptor potential cation channel subfamily V member 4.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
urogenital diseasesD000091642
hereditary congenital and neonatal diseases and abnormalitiesD009358
nutritional and metabolic diseasesD009750
Trade Name
FDA
EMA
Combinations
Clenpiq, Phexxi, Picosulfate, magnesium oxide anhydrous citric acid, Renacidin (discontinued: Irrigating solution g, Prepopik, Urologic g)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Citric acid
+
Magnesium oxide
+
Sodium carbonate
Tradename
Company
Number
Date
Products
IRRIGATING SOLUTION G IN PLASTIC CONTAINERBaxterN-018519 DISCN1982-06-22
1 products
UROLOGIC G IN PLASTIC CONTAINERHospiraN-018904 DISCN1983-05-27
1 products
Hide discontinued
Citric acid
+
Magnesium oxide
+
Sodium picosulfate
Tradename
Company
Number
Date
Products
CLENPIQFerring PharmaceuticalsN-209589 RX2017-11-28
1 products, RLD, RS
Show 1 discontinued
Citric acid
+
Lactic acid
+
Potassium bitartrate
Tradename
Company
Number
Date
Products
PHEXXIEvofem BiosciencesN-208352 RX2020-05-22
1 products, RLD, RS
Citric acid
+
Gluconolactone
+
Magnesium carbonate
Tradename
Company
Number
Date
Products
RENACIDINUnited GuardianN-019481 RX1990-10-02
1 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
2080 dentistry night freshOTC monograph final2017-02-03
abstralNew Drug Application2014-11-30
acdANDA2025-01-22
acd blood-pack units (pl 146 plastic)New Drug Application2022-04-27
acd-aNew Drug Application2022-11-01
acetaminophen and diphenhydramine citrateC2002632025-10-02
additive formula 3New Drug Application2025-01-24
adea gargleunapproved drug other2018-03-26
adsol red cell preservationNew Drug Application2022-11-22
adsol red cell preservation solution system in plastic container (pl 146 plastic)New Drug Application2022-11-02
Show 221 more
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
urination disorders—D014555—
renal tubular acidosis—D000141N25.89
dermatitis—D003872L30.9
facial dermatoses—D005148—
Agency Specific
FDA
EMA
Expiration
Code
CITRIC ACID / LACTIC ACID / POTASSIUM BITARTRATE, PHEXXI, EVOFEM INC
2023-05-22NP
Patent Expiration
Patent
Expires
Flag
FDA Information
Citric Acid / Magnesium Oxide / Sodium Picosulfate, Clenpiq, Ferring Pharms Inc
98272312034-06-26DPU-2162
106248792034-06-23DP
111917532034-06-23U-3261
Citric Acid / Lactic Acid / Potassium Bitartrate, Phexxi, Evofem Inc
105688552033-03-15U-1
113379892033-03-15U-1
114396102033-03-15DS, DP
67062762023-09-06DP
Citric Acid / Magnesium Oxide / Sodium Picosulfate, Prepopik, Ferring Pharms Inc
84503382028-10-10DP
84810832028-10-10DP
ATC Codes
A: Alimentary tract and metabolism drugs
— A09: Digestives, incl. enzymes
— A09A: Digestives, incl. enzymes
— A09AB: Acid preparations, digestives
— A09AB04: Citric acid
HCPCS
No data
Clinical
Clinical Trials
2240 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Acute kidney injuryD058186—N17——2——2
Continuous renal replacement therapyD000079664————2——2
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
SepsisD018805EFO_0001420A41.9————11
ThromboinflammationD000090882——————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameCitric acid
INNdimpylate
Description
Idkit:hp (citric acid) is a small molecule pharmaceutical. Citric acid was first approved as Idkit:hp on 2002-12-17. It is used to treat renal tubular acidosis and urination disorders in the USA. It is known to target polycystic kidney disease 2-like 1 protein, transient receptor potential cation channel subfamily V member 4, and nectin-1.
Classification
Small molecule
Drug class—
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
O=C(O)CC(O)(CC(=O)O)C(=O)O
Identifiers
PDB—
CAS-ID77-92-9
RxCUI—
ChEMBL IDCHEMBL1261
ChEBI ID30769
PubChem CID311
DrugBankDB04272
UNII IDXF417D3PSL (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
PKD2L1
PKD2L1
NECTIN1
NECTIN1
Organism
Homo sapiens
Gene name
PKD2L1
Gene synonyms
PKD2L, PKDL, TRPP3
NCBI Gene ID
9033
Protein name
polycystin-2-like protein 1
Protein synonyms
Polycystic kidney disease 2-like 1 protein, Polycystin-2 homolog, polycystin-2L1, Polycystin-L, Polycystin-L1, transient receptor potential cation channel, subfamily P, member 3
Uniprot ID
Q9P0L9
Mouse ortholog
Pkd2l1 (329064)
polycystin-2-like protein 1; polycystic kidney disease 2-like 1 protein (Q80ZH4)
Variants
No data
Financial
Revenue by drug
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Revatio – Pfizer
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Miplyffa – Zevra Therapeutics
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Viagra – Viatris
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Viagra – Pfizer
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Lazanda – Assertio Therapeutics
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Phexxi – Evofem Biosciences
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Auryxia – Keryx Biopharmaceuticals
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Tabular view
Estimated US medical usage
Citric acid
+
Citric acid monohydrate
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 448,969 documents
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Safety
Black-box Warning
Black-box warning for: Abstral, Citranatal, Citranatal assure, Citranatal essence, Citranatal harmony, Citranatal harmony 2.1, Citranatal harmony 3.0, Citranatal medley, Fareston, Fentanyl buccal, Fentanyl citrate, Hepzato kit, Lazanda, Melphalan hydrochloride, Soltamox, Sufentanil citrate, Tamoxifen citrate, Toremifene citrate, Transmucosal fentanyl citrate
Adverse Events
Top Adverse Reactions
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49,654 adverse events reported
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